A new Centers for Disease Control and Prevention report titled, Influenza, COVID-19, and Respiratory Syncytial Virus Vaccination Coverage Among Adults — United States, Fall 2024, found that, by November 9, 2024, only an estimated 17.9% of adults aged ≥18 years had received the updated COVID-19 booster injection. Approximately 13.5% of adults indicate that they “definitely will get vaccinated.” This means that the vast majority of Americans reject novel genetic booster shots designed on a computer screen with no human data. These estimates were derived using a ‘nondecreasing composite estimation procedure’ combining completed interviews from the current and previous weeks. Because the data are self-reported, they are subject to recall or social desirability bias, which could result in overestimation of true uptake. In other words, true COVID-19 booster uptake may be even lower.