Too much synthetic folic acid from supplements and fortified foods may harm brain development and could be involved in rising rates of neurodevelopmental disorders in children.

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It’s extremely rare to get too much folate from foods, but it is possible to get too much folic acid, the synthetic version of folate found in supplements and fortified foods.
In pregnant mice, high levels of folic acid harmed brain development in offspring, and low levels of vitamin B12 made the damage worse.
The combination of low vitamin B12, which often occurs in people eating vegan or vegetarian diets, along with high folic acid, could be increasing neurodevelopment disorders in children.
Due to prenatal supplements and fortified foods, many people have abnormally high levels of folic acid.
Studies looking into the effects of folic acid on autism development are conflicting, with some showing a protective effect, but a growing body of evidence points to potential harms when consumed in excess.

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