Persistent lymphopenia is a hallmark of immune deficiency, which can put people at risk of opportunistic infections including reactivated viruses.

After a COVID-19 infection or inoculation with its vaccine, some people develop reactivated and recurrent infections, including herpes, Epstein-Barr virus (EBV), urinary tract infections (UTIs), and even COVID-19.

Some emerging studies are linking this phenomenon to lymphopenia, or low numbers of lymphocytes.
Lymphocytes are a large group of immune cells, including natural killer cells, that play significant roles in killing cancer and infected cells. The body’s final line of defense, B and T cells, are also lymphocytes.

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