Girls who received the quadrivalent HPV vaccine had 4.4 times the risk of developing rheumatoid arthritis and 2.9 times the risk of thyrotoxicosis.

A new study suggests the quadrivalent vaccine against human papillomavirus (qHPV) may increase the risk of developing several autoimmune diseases.

A retrospective cohort study published on March 7 in Vaccine found that adolescent women who were vaccinated were 4.4 times more likely to develop rheumatoid arthritis than those who were not vaccinated. Similarly, vaccinated adolescent women had a 2.76 times higher chance of developing juvenile idiopathic arthritis.

The study found that females who received the qHPV vaccine had a 2.86 times higher risk of developing thyrotoxicosis, while the risk of developing idiopathic thrombocytopenic purpura (ITP) was 2.54 times higher in the vaccinated group. Thyrotoxicosis causes inappropriately high levels of circulating thyroid hormone, and ITP is a blood disorder characterized by an abnormal decrease in blood platelets.

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