What does the “Alzheimer’s gene” reveal about the link between Alzheimer’s disease and cholesterol transport in the body?
How is cholesterol transport dependent on the “mystery molecule”—plasmalogen—that can restore brain health?
In 1990, the Human Genome Project began to map the DNA instructions in human cells. This led to discovering the APOE4 gene’s link to higher Alzheimer’s disease risk.
On Vital Signs with Brendon Fallon, Dayan Goodenowe explains this gene’s crucial role in cholesterol regulation. One factor makes it more relevant to understanding and treating Alzheimer’s than the irregular (amyloid and tau) protein build-ups in the brain that have long been the target of Alzheimer’s treatment.

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