While the mainstream medical community — to the extent it is interested in preventing/treating disease in the first place and not just capitalizing off of it — has long held that the buildup of amyloid and tau proteins in the brain is the precipitating cause of Alzheimer’s disease, along with other degenerative conditions of the brain, the true cause may be much simpler and, critically, much more simply prevented/treated.
First, it’s important to understand what amyloid proteins do and why they are found in the nervous system tissue in the first place.
The human immune system has two components: the innate immune system and the adaptive immune system. As the terms suggest, the former is the frontline of defense against pathogens and the latter is comprised of antibodies produced in response to prior encountered pathogens.
The brain, probably for evolutionary reasons, has limited adaptive immunity and relies heavily on innate immunity, of which amyloid plaques are an important part.
Via Science Translational Medicine:
“Neurodegeneration in Alzheimer’s disease (AD) is mediated by soluble oligomeric intermediates generated during fibrillization of the amyloid-β protein (Aβ)…