From 2018 to 2022, thousands of US children were given puberty blockers or hormones as treatment for the mental illness known as gender dysphoria. That’s according to a newly published research letter that attempted to quantify how common the controversial treatments are.

Studies have indicated that many factors are contributing to hormone disruption in humans. These include medicine, pesticides, plastics, and other chemicals in food and water.

According to the article, published in the Journal of the American Medical Association (JAMA) Pediatrics, the numbers were gathered from the records of five million privately-insured children aged 8-17. Among them, nearly 1,000 (926) adolescents were given puberty blocking drugs from 2018 through 2022, and nearly 2,000 (1,927) were given hormones. JAMA reportedly gets most of its advertising revenue from drug companies.